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Pronunciation(tye oh KONE a zole)
U.S. Brand Names1-Day™ [OTC]; Vagistat®-1 [OTC]
Generic AvailableNo
UseLocal treatment of vulvovaginal candidiasis
Pregnancy Risk FactorC
LactationExcretion in breast milk unknown/not recommended
ContraindicationsHypersensitivity to tioconazole or any component of the formulation
Warnings/PrecautionsFor vaginal use only. Petrolatum-based vaginal products may damage rubber or latex condoms or diaphragms. Separate use by 3 days.
Adverse ReactionsFrequency not defined. Central nervous system: Headache
Gastrointestinal: Abdominal pain
Dermatologic: Burning, desquamation
Genitourinary: Discharge, dyspareunia, dysuria, irritation, itching, nocturia, vaginal pain, vaginitis, vulvar swelling
Drug InteractionsInhibits CYP1A2 (weak), 2A6 (weak), 2C8/9 (weak), 2C19 (weak), 2D6 (weak), 2E1 (weak) No drug interaction data reported.
StabilityStore at room temperature.
Mechanism of ActionA 1-substituted imidazole derivative with a broad antifungal spectrum against a wide variety of dermatophytes and yeasts, including Trichophyton mentagrophytes, T. rubrum, T. erinacei, T. tonsurans, Microsporum canis, Microsporum gypseum, and Candida albicans. Both agents appear to be similarly effective against Epidermophyton floccosum.
Pharmacodynamics/KineticsOnset of action: Some improvement: Within 24 hours; Complete relief: Within 7 days
Absorption: Intravaginal: Systemic (small amounts)
Distribution: Vaginal fluid: 24-72 hours
Excretion: Urine and feces
DosageAdults: Vaginal: Insert 1 applicatorful in vagina, just prior to bedtime, as a single dose
AdministrationInsert high into vagina
Patient EducationConsult with healthcare provider if treating a vaginal yeast infection for the first time. Insert high into the vagina. Refrain from intercourse during treatment. May interact with condoms and vaginal contraceptive diaphragms (ie, weaken latex); do not rely on these products for 3 days following treatment. Do not use tampons, douches, spermicides, or other vaginal products during treatment. Although product is used for a single day, relief from symptoms usually takes longer than 1 day. Report persistent (>3 days) vaginal burning, irritation, or discharge. Breast-feeding precaution: Breast-feeding is not recommended.
Dental Health: Effects on Dental TreatmentNo significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic PrecautionsNo information available to require special precautions
Mental Health: Effects on Mental StatusNone reported
Mental Health: Effects on Psychiatric TreatmentNone reported
Dosage FormsOintment, vaginal: 6.5% (4.6 g) [with applicator]
International Brand NamesConasyd® (BD); Deocil Fem® (AR); Dermo-Rest® (TR); Dermo-Trosyd® (TR); Gino Tralen® (BR); Ginotrosyd® (IT); Gino-Trosyd® (PT); Gyno-Trosyd® (CH, CO, EG, FI, FR, HK, PL, SG, TR, ZA); Honguil® (AR); Mykontral® (DE); Tinazol® (BR); Tiocan® (TR); Tioconazol Genfar® (EC); Tiomicol® (AR); Tralen® (BR); Trosderm® (ES); Trosid® (ES); Trosyd® (AR, AT, CH, CL, CO, EG, FI, FR, HK, ID, IT, PT, SG, TH, ZA); Trosyl® (GB, IE)
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A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited. |
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