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    Macroamylasemia

    Definition

    Macroamylase is a molecule that consists of an enzyme, called amylase, bound to a protein. Because it is relatively large, macroamylase is filtered very slowly from the blood by the kidneys. Macroamylasemia is when this molecule builds up in the blood.

    Macroamylasemia has been associated with:

    • celiac disease
    • ulcerative colitis
    • rheumatoid arthritis
    • lymphoma
    • HIV infection
    • monoclonal gammopathy

    Symptoms

    Macroamylasemia does not cause symptoms.

    Exams and Tests

    Macroamylasemia causes a high amylase blood level reading.

    Macroamylasemia can be confused with acute pancreatitis, which also causes high levels of amylase in the blood.

    Macroamylasemia can be diagnosed by measuring amylase levels in the urine. Urine levels of amylase would be low. This is in contrast to acute pancreatitis, in which urine amylase levels will be high.


    Review Date: 11/10/2004
    Reviewed By: Christian Stone, M.D., Division of Gastroenterology, Washington University in St. Louis School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network.
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