Malaise is a generalized feeling of discomfort, illness, or lack of well-being that can be associated with a disease state. It can be accompanied by a sensation of exhaustion or inadequate energy to accomplish usual activities.

Malaise is a nonspecific symptom that can occur with almost any significant infectious, metabolic (endocrine), or systemic disorder. The onset may be slow or rapid depending on the nature of the disease.

Fatigue accompanies malaise in many common diseases.

The following lists give examples of the diseases and conditions that can cause malaise.

ACUTE INFECTIOUS DISEASE

• Influenza
• Acute bronchitis or pneumonia
• Acute viral syndrome
• Lyme disease
• Infectious mononucleosis (EBV)

CHRONIC INFECTIOUS DISEASE

• AIDS
• Tuberculosis
• Parasitic disease
• Chronic active hepatitis

CARDIOPULMONARY

• Emphysema or COPD
• Congestive heart failure

ORGAN FAILURE

• Acute or chronic kidney disease
• Acute or chronic liver disease

CONNECTIVE TISSUE DISEASE

• Rheumatoid arthritis
• Systemic lupus erythematosus
• Sarcoidosis

ENDOCRINE or METABOLIC

• Thyroid disease
• Diabetes
• Pituitary gland dysfunction (rare)
• Adrenal gland dysfunction

NEOPLASTIC

• Lymphoma
• Leukemia
• Solid tumor malignancies, such as colon cancer

BLOOD DISORDERS

• Severe anemia

Significant symptoms require prompt attention from your medical provider

• Malaise is accompanied by other symptoms indicating a significant illness.
• Malaise persists longer than one week, with or without other symptoms.

Your health care provider will perform a physical examination and ask questions such as:

• How long has it lasted (weeks or months)?
• What other symptoms do you have?
• Is the malaise constant or episodic?
• Can you complete your daily activities? If not what limits you?
• Have you recently traveled?
• What medications are you on?
• What are your other medical problems?
• Do you use alcohol or other drugs?